| Interpretatie: | Toxische concentratie mirtazapine is onbekend.
Desmethylmirtazapine draagt nauwelijks bij aan de farmacologische werking (max 5-10% van de activiteit van mirtazapine zelf) maar wordt wel bepaald omdat de ratio meer informatie kan geven over het juiste afname moment, therapietrouw, normaal metabolisme en interacties.
Normale ratio desmethylmirtazapine - mirtazapine: 0.2 - 1.2
Normale som spiegel mirtazapine - desmethylmirtazapine 50-300 ug/L.
Bij de interpretatie van de resultaten dient rekening gehouden te worden met de meetonzekerheid van de analysemethode. Voor meer informatie kunt u terecht bij de laboratoriumapotheker. |
| Bronvermelding: | -Hiemke et al. AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011. pharmacospychiatry 44:195-235
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- TDM monografie NVZA mirtazapine (www.tdm-monografie.org)
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